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我总觉得R2最大的缺点就是情节跳的太快了. 当然看R1的时候也是好久只前了, 所以可能R1也有这种毛病吧. 其实R1留下的最大的一个迷团就是教团和Geass, 但R2引入的也太快了一点吧. 而且人物的感情也太夸张了一点. 杰瑞米牙的转变MS太突然了一点吧. 不过XL的死估计不是RORO杀的, 估计不是, 不然RORO就太那个什么了.

Tumor-Induced Suppressor of Cytokine Signaling 3 Inhibits Toll-like Receptor 3 Signaling in Dendritic Cells via Binding to Tyrosine Kinase 2

 

Bin Zeng, Haijie Li, Yu Liu, Zhuohan Zhang, Yuan Zhang, and Rongcun Yang

 

Cancer Res 2008; 68: (13). July 1, 2008

 

The suppressor of cytokine signaling (SOCS) family of negative regulatory proteins is up-regulated in response to several cytokines and pathogen-associated molecular patterns (PAMP) and suppresses cellular signaling responses by binding receptor phosphotyrosine residues.E xposure of bone marrow–derived dendritic cells (BMDC) to 1D8 cells, a murine model of ovarian carcinoma, suppresses their ability to express CD40 and stimulate antigen-specific responses in response to PAMPs and, in particular, to polyinosinic acid:poly-CMP (polyI:C) with the up-regulated SOCS3 transcript and protein levels.The ectopic expression of SOCS3 in both the macrophage cell line RAW264.7 and BMDCs decreased signaling in response to both polyI:C and IFNA. Further, knockdown of SOCS3 transcripts significantly enhanced the responses of RAW264.7 and BMDCs to both polyI:C and IFNA.Immunoprecip itation and pull-down studies show that SOCS3 binds to the IFNA receptor tyrosine kinase 2 (TYK2).Because polyI:C triggers autocrine IFNA signaling, binding of SOCS3 to TYK2 may thereby suppress the activation of BMDCs by polyI:C and IFNA.Thus, elevated levels of SOCS3 in tumor-associated DCs may potentially resist the signals induced by Toll-like receptor 3 ligands and type I IFN to decrease DC activation via binding with IFNA receptor TYK2.

 

本期的”中国科技”是一篇由南开大学在”癌症研究”上发表的文章. 文章主要想讲的是, 当免疫细胞接触癌症细胞后, 癌症细胞在免疫细胞里引发SOCS. SOCS的主要功能是降低免疫细胞产生抗体的数量. 我觉得这篇文章很有趣, 但文章中只用了一种癌症细胞线, 而且也没说明为什么要选择这个癌症细胞线. 是不是应该用多一点不同类型的细胞线呢? 而且我觉得更有意思要去问的问题, 应该是癌症细胞是怎样在免疫细胞里引发SOCS的.

 

这是我看这片子的最后一集了. 实在太低龄了, 而且居然是bones做的. 最近我身体也不是很好, 这种片子看多了伤身体.

 

PS我最近看完了无限的未知. 我估计会给它一个7/10. 20集后崩的厉害, 结尾也没有把握好(个人观点).